Virginia Todisco was born in Naples and studied singing at the Salerno Conservatory and with her father, the tenor Nunzio Todisco.
In 1998 the young soprano made her debut at the Teatro Municipal di Rio de Janeiro as Elisabetta in Verdi’s Don Carlo. The following year she sang Manon|Manon Lescaut at the Teatro Massimo di Palermo, Leonora|Trovatore at the Teatro Bellini in Catania and again Manon Le-scaut at the Teatro Coccia in Novara.
In 2000 Virginia Todisco made her debut as Santuzza in Mascagni’s Cavalleria Rusticana at the Teatro Filarmonico in Verona.
In the same season in Marseille she was chosen to play the title role in the world premiere of Alberic Magnard’s new opera Bérénice. The premiere was a personal success for the young singer and was broadcast on French radio and worldwide on TV.
In 2002 the soprano made her debut as Manon Lescaut in Venice at the Teatro La Fenice.
In 2003 she sang her first Leonora|La Forza del Destino for Opera Catalunya in Spain, debuted as Aida at the Festival in the Ruins of Tyre in Lebanon and returned to the Teatro Massimo in Palermo as Elisabetta|Don Carlo.
In 2004 she sang Santuzza at the Opera of Rome, in 2005 followed a production of Don Carlo at the Megaron of Athens and Aida at the Caracalla – Thermae.

In April 2008 Virginia Todisco made her debut – also at the Rome Opera – as Minnie|La Fanciulla del West. Afterwards she sang Maddalena|Andrea Chénier for the first time at the Stadttheater Gießen. In the season 2008/09 she made her debut in the title role of Aida in Baltimore, in 2009 she sang Tosca in Rome.
The repertoire of Virginia Todisco includes the soprano leading roles in: Ballo in Maschera, Il Trovatore, Don Carlo, Ernani, Otello, Aida, Tosca, La Forza del destino, Il Tabarro, Manon Lescaut, Cavalleria Rusticana and Andrea Chénier.